3 research outputs found
Generating Software for Well-Understood Domains
Current software development is often quite code-centric and aimed at
short-term deliverables, due to various contextual forces (such as the need for
new revenue streams from many individual buyers). We're interested in software
where different forces drive the development. \textbf{Well understood domains}
and \textbf{long-lived software} provide one such context.
A crucial observation is that software artifacts that are currently
handwritten contain considerable duplication. By using domain-specific
languages and generative techniques, we can capture the contents of many of the
artifacts of such software. Assuming an appropriate codification of domain
knowledge, we find that the resulting de-duplicated sources are shorter and
closer to the domain. Our prototype, Drasil, indicates improvements to
traceability and change management. We're also hopeful that this could lead to
long-term productivity improvements for software where these forces are at
play.Comment: 12 pages, paper accepted at EVCS 202
Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samples
The polymorphism in the serotonin transporter gene promoter region (5-HTTLPR) is by far the most studied variant hypothesized to influence Neuroticism-related personality traits. The results of previous studies have been mixed and appear moderated by the personality questionnaire used. Studies that used the TCI to assess Harm Avoidance or the EPQ to assess Neuroticism have found no association with the 5-HTTLPR. However, studies that used the NEO-PI-R or related instruments (NEO-PI, NEO-FFI) to measure Neuroticism have found some evidence of association. This study examines the association of variants in the serotonin transporter gene in a sample from a genetically isolated population within Sardinia (Italy) that is several times larger than previous samples that used the NEO-PI-R (N = 3,913). The association was also tested in a sample (N = 548) from the Baltimore Longitudinal Study of Aging (BLSA), in which repeated NEO-PI-R assessments were obtained. In the SardiNIA sample, we found no significant association of the 5-HTTLPR genotypes with Neuroticism or its facets (Anxiety, Angry-Hostility, Depression, Self-Consciousness, Impulsiveness, and Vulnerability). In the BLSA sample, we found lower scores on Neuroticism traits for the heterozygous group, which is inconsistent with previous studies. We also examined eight SNPs in the SardiNIA (N = 3,972) and nine SNPs in the BLSA (N = 1,182) that map within or near the serotonin transporter gene (SLC6A4), and found no association. Along with other large studies that used different phenotypic measures and found no association, this study substantially increases the evidence against a link between 5-HTT variants and Neuroticism-related traits. © 2009 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/64573/1/30932_ftp.pd